A Gata2 intronic enhancer confers its pan-endothelia-specific regulation
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چکیده
منابع مشابه
A Gata2 intronic enhancer confers its pan-endothelia-specific regulation.
GATA-2, a transcription factor that has been shown to play important roles in multiple organ systems during embryogenesis, has been ascribed the property of regulating the expression of numerous endothelium-specific genes. However, the transcriptional regulatory hierarchy governing Gata2 activation in endothelial cells has not been fully explored. Here, we document GATA-2 endothelial expression...
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The aim of this study was to determine the genetic regulation of macrophage migration inhibitory factor (MIF). DNase I hypersensitivity was used to identify potential hypersensitive sites (HS) across the MIF gene locus. Reporter gene assays were performed in different human cell lines with constructs containing the native or mutated HS element. Following phylogenetic and transcription factor bi...
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Transcription factor GATA2 is expressed in numerous mammalian tissues, including neural, hematopoietic, cardiovascular and urogenital systems, and yet it plays important roles in the regulation of tissue-restricted gene expression. The Gata2 gene itself is also under stringent tissue-specific control and multiple cis-regulatory domains have been identified in the Gata2 locus. In this study we s...
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Fig. 18 Shown are the regulatory elements characterized so far, which control the transcription of the tyrosine aminotransferase (TAT) gene. The TAT gene may be induced either by glycocorticoids or by cyclic adenosine monophosphate (cAMP), which activates the protein kinase A. All distances are given in kilobases (kb) and refer to the starting point of the TAT gene transcription (arrow). mediat...
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ژورنال
عنوان ژورنال: Development
سال: 2007
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.001297